Hepatitis B vaccine (Heplisav-B) cost in Chicago, IL
In Chicago-Naperville-Elgin, IL-IN, 27 hospitals list a cash price for hepatitis B vaccine, adult, 2-dose schedule (Heplisav-B): from $48.51 to $1,831.62, with a median of $320.30. The lowest listed price is at Humboldt Park Health — $271.79 less than the median here. Across Illinois, the median is $224.28 at 39 hospitals.
Cash prices at 27 facilities across 22 cities for code 90739, as an outpatient — the setting a self-pay patient normally buys. Collected Sep 27, 2026; the hospital files themselves were last updated between Mar 31, 2026 and Aug 24, 2026.
Lowest$48.51Humboldt Park Health
Median$320.30half of hospitals charge less
Highest$1,831.62in this market
Difference37.8×highest vs lowest
Where each hospital's price falls
Each dot is one hospital's cash price on a scale from the lowest to the highest in Chicago-Naperville-Elgin, IL-IN.
median
Lowest $48.51Highest $1,831.62
Hospitals, cheapest first
| Hospital | Cash price | List price | Insurers pay | Off list |
|---|---|---|---|---|
| Humboldt Park Health lowest Chicago, IL · (773) 292-8200 Hepatitis B vaccine (HepB), CpG-adjuvanted, adult dosage, 2 dose or 4 dose schedule, for intramuscular use File of Aug 24, 2026 · source file | $48.51 | $173.25 | $173.25 | 72% |
| MacNeal Hospital Berwyn, IL · (708) 783-9100 Hepatitis B Adult Heplisav-B 2-Dose Sch Im Inj (Fc) File of Mar 31, 2026 · source file | $68.21 | $359.00 | $68.21–$497.22 | 81% |
| Gottlieb Memorial Hospital Melrose Park, IL · (708) 681-3200 Hepatitis B Adult Heplisav-B 2-Dose Sch Im Inj (Fc)+1 more line at this price File of Mar 31, 2026 · source file | $68.21 | $359.00 | $108.06–$300.84 | 81% |
| Loyola University Medical Center Maywood, IL · (708) 216-9000 Hepatitis B Adult Heplisav-B 2-Dose Sch Im Inj (Fc)+1 more line at this price File of Mar 31, 2026 · source file | $82.57 | $359.00 | $36.28–$378.39 | 77% |
| The University of Chicago Medical Center Chicago, IL · (773) 702-9785 Hc Hepb Vacc 2 Dose Adult Im Employee Health File of Apr 1, 2026 · source file | $145.00 | $145.00 | — | — |
| Uchicago Medicine AdventHealth Glenoaks Glendale Heights, IL · (630) 545-8000 HEPATITIS B VAC RECOMB ADJ 20 MCG/0.5ML IM SOSY File of Apr 1, 2026 · source file | $185.29 | $741.14 | — | 75% |
| Uchicago Medicine AdventHealth La Grange La Grange, IL · (708) 352-1200 HEPATITIS B VAC RECOMB ADJ 20 MCG/0.5ML IM SOSY File of Apr 1, 2026 · source file | $185.29 | $741.14 | — | 75% |
| Uchicago Medicine AdventHealth Bolingbrook Bolingbrook, IL · (630) 312-5000 HEPATITIS B VAC RECOMB ADJ 20 MCG/0.5ML IM SOSY File of Apr 1, 2026 · source file | $185.29 | $741.14 | — | 75% |
| Uchicago Medicine AdventHealth Hinsdale Hinsdale, IL · (630) 856-9000 HEPATITIS B VAC RECOMB ADJ 20 MCG/0.5ML IM SOSY File of Apr 1, 2026 · source file | $185.29 | $741.14 | — | 75% |
| NorthShore University HealthSystems Skokie Hospital Skokie, IL Hepatitis B Vacc Adult 2 Dose Im source file | $212.55 | $327.00 | $44.15–$178.54 | 35% |
| NorthShore University HealthSystems Glenbrook Hospital Glenview, IL Hepatitis B Vacc Adult 2 Dose Im source file | $212.55 | $327.00 | $44.15–$178.54 | 35% |
| Presence Saint Joseph Hospital - Chicago Chicago, IL · (773) 665-3000 HEPATITIS B VAC RECOMB ADJ 20 MCG/0.5ML IM SOSY+1 more line at this price source file | $302.43 | $916.46 | $195.54–$458.23 | 67% |
| The University of Chicago Medical Center Chicago, IL · (773) 702-9785 Pr Hepb Vaccine Adult 2/4 Dose Schedule For Im Use+1 more line at this price File of Apr 1, 2026 · source file | $306.00 | $306.00 | — | — |
| The Methodist Hospitals Gary, IN · (219) 886-4000 HEPATITIS B VAC RECOMBINANT 10 MCG/0.5ML IJ SUSY [180147] source file | $320.30 | $457.57 | $0.01–$407.24 | 30% |
| Methodist Hospital-Southlake Merrillville, IN · (219) 886-4000 HEPATITIS B VAC RECOMBINANT 10 MCG/0.5ML IJ SUSY [180147] source file | $320.30 | $457.57 | $0.01–$407.24 | 30% |
| Swedish Covenant Health Chicago, IL · (773) 878-8200 HEPATITIS B VACC ADULT 2 DOSE IM File of Apr 1, 2026 · source file | $362.00 | $362.00 | — | — |
| Endeavor Health Highland Park Hospital Highland Park, IL HEPATITIS B VACC ADULT 2 DOSE IM File of Apr 1, 2026 · source file | $362.00 | $362.00 | — | — |
| Northshore University Healthsystem - Evanston Hospital Evanston, IL · (847) 570-2000 HEPATITIS B VACC ADULT 2 DOSE IM File of Apr 1, 2026 · source file | $362.00 | $362.00 | — | — |
| Northwestern Medicine McHenry Hospital McHenry, IL · (815) 344-5000 HB Heplisav Hepb Vaccine Adult 2 Dose Schedule for Im Use File of Apr 1, 2026 · source file | $440.30 | $629.00 | $121.40–$629.00 | 30% |
| Northwestern Lake Forest Hospital Lake Forest, IL · (847) 234-5600 HB Heplisav Hepb Vaccine Adult 2 Dose Schedule for Im Use File of Apr 1, 2026 · source file | $440.30 | $629.00 | $104.41–$629.00 | 30% |
| Palos Community Hospital Palos Heights, IL · (708) 923-4000 HB Heplisav Hepb Vaccine Adult 2 Dose Schedule for Im Use File of Apr 1, 2026 · source file | $440.30 | $629.00 | $100.64–$629.00 | 30% |
| Northwestern Medicine Central DuPage Hospital Winfield, IL · (630) 682-1600 HB Heplisav Hepb Vaccine Adult 2 Dose Schedule for Im Use File of Apr 1, 2026 · source file | $440.30 | $629.00 | $43.40–$629.00 | 30% |
| Northwestern Memorial Hospital Chicago, IL · (312) 926-2000 HB Heplisav Hepb Vaccine Adult 2 Dose Schedule for Im Use File of Apr 1, 2026 · source file | $440.30 | $629.00 | $122.03–$629.00 | 30% |
| Northwestern Medicine Valley West Hospital Sandwich, IL · (815) 786-8484 HB Heplisav Hepb Vaccine Adult 2 Dose Schedule for Im Use File of Apr 1, 2026 · source file | $440.30 | $629.00 | $119.51–$629.00 | 30% |
| Northwestern Medicine Delnor Hospital Geneva, IL · (630) 208-3000 HB Heplisav Hepb Vaccine Adult 2 Dose Schedule for Im Use File of Apr 1, 2026 · source file | $440.30 | $629.00 | $93.72–$629.00 | 30% |
| Northwestern Medicine Marianjoy Rehabilitation Hospital Wheaton, IL HB Heplisav Hepb Vaccine Adult 2 Dose Schedule for Im Use File of Apr 1, 2026 · source file | $440.30 | $629.00 | $264.18–$629.00 | 30% |
| Northwestern Medicine Kishwaukee Hospital DeKalb, IL · (815) 756-1521 HB Heplisav Hepb Vaccine Adult 2 Dose Schedule for Im Use File of Apr 1, 2026 · source file | $440.30 | $629.00 | $115.11–$629.00 | 30% |
| Palos Community Hospital Palos Heights, IL · (708) 923-4000 HEPATITIS B VACC-CPG 1018 (PF) 20 MCG/0.5 ML IM SYRG File of Apr 1, 2026 · source file | $527.27 | $753.25 | $120.52–$753.25 | 30% |
| Methodist Hospital-Southlake Merrillville, IN · (219) 886-4000 HEPATITIS B VAC RECOMB ADJ 20 MCG/0.5ML IM SOSY [164614] source file | $585.44 | $836.34 | $0.01–$744.34 | 30% |
| The Methodist Hospitals Gary, IN · (219) 886-4000 HEPATITIS B VAC RECOMB ADJ 20 MCG/0.5ML IM SOSY [164614] source file | $585.44 | $836.34 | $0.01–$744.34 | 30% |
| Northwestern Medicine McHenry Hospital McHenry, IL · (815) 344-5000 HEPATITIS B VACC-CPG 1018 (PF) 20 MCG/0.5 ML IM SYRG File of Apr 1, 2026 · source file | $603.92 | $862.75 | $166.51–$862.75 | 30% |
| Uchicago Medicine AdventHealth Hinsdale Hinsdale, IL · (630) 856-9000 HEPATITIS B VACCINE 20 MCG/0.5 ML-ADJUVANT CPG 1018 (PF) IM SYRINGE File of Apr 1, 2026 · source file | $626.12 | $1,043.53 | — | 40% |
| Northwestern Medicine Delnor Hospital Geneva, IL · (630) 208-3000 HEPATITIS B VACC-CPG 1018 (PF) 20 MCG/0.5 ML IM SYRG File of Apr 1, 2026 · source file | $708.75 | $1,012.50 | $150.86–$1,012.50 | 30% |
| Northwestern Memorial Hospital Chicago, IL · (312) 926-2000 HEPATITIS B VACC-CPG 1018 (PF) 20 MCG/0.5 ML IM SYRG File of Apr 1, 2026 · source file | $708.75 | $1,012.50 | $148.36–$1,562.75 | 30% |
| Northwestern Medicine Valley West Hospital Sandwich, IL · (815) 786-8484 HEPATITIS B VACC-CPG 1018 (PF) 20 MCG/0.5 ML IM SYRG File of Apr 1, 2026 · source file | $710.50 | $1,015.00 | $192.85–$1,015.00 | 30% |
| Northwestern Medicine Kishwaukee Hospital DeKalb, IL · (815) 756-1521 HEPATITIS B VACC-CPG 1018 (PF) 20 MCG/0.5 ML IM SYRG File of Apr 1, 2026 · source file | $893.20 | $1,276.00 | $233.51–$1,276.00 | 30% |
| The University of Chicago Medical Center Chicago, IL · (773) 702-9785 NDC Description Not Available File of Apr 1, 2026 · source file | $1,001.62 | $1,001.62 | — | — |
| Northwestern Medicine Central DuPage Hospital Winfield, IL · (630) 682-1600 HEPATITIS B VACC-CPG 1018 (PF) 20 MCG/0.5 ML IM SYRG File of Apr 1, 2026 · source file | $1,093.92 | $1,562.75 | $107.83–$1,562.75 | 30% |
| John H. Stroger, Jr. Hospital Chicago, IL · (312) 864-6000 HEPATITIS B ADULT VACCINE (HEPLISAV-B) 20 MCG/0.5 ML source file | $1,831.62 | $2,616.60 | $183.79–$2,093.28 | 30% |
Hospital The hospital that published the price, its city and the line exactly as written in its price file.
Cash price The hospital's own price for a patient paying without insurance (“discounted cash” in its price file). Hospitals must publish it under federal law, 45 CFR 180.50. Call to confirm it before booking.
List price The hospital's full chargemaster price (“gross charge”) before any discount. Almost nobody pays it; the gap to the cash price shows what the self-pay discount is worth.
Insurers pay The lowest and highest rates this hospital has agreed with insurance plans for the same item, from its price file. If the cash price is below what your plan pays and you have not met your deductible, paying cash can cost you less.
Off list How much lower the cash price is than the list price.
No cash discount This line's cash price equals the hospital's full list price. Many hospitals still reduce bills for uninsured patients: ask the billing office for its self-pay discount in writing.
Outpatient: lowest $48.51, median $320.30, highest $1,831.62 — a 37.8× difference within the same market.
As an inpatient, the same code is billed by 15 facilities here, median $185.29. Inpatient and outpatient prices are not comparable and are kept on separate pages: the inpatient charge covers admission, not the same purchase.
Cash or insurance?
At 17 of 19 hospitals that publish insurer rates for this code here, the cash price is below the highest rate a health plan has negotiated, and at 3 it is below every plan's rate. If you have insurance but have not met your deductible, you usually pay your plan's negotiated rate, which falls somewhere in the "Insurers pay" column. Paying cash can cost less, but a cash payment usually does not count toward your deductible. Ask the hospital for both numbers before you book.
What it is
Heplisav-B is a hepatitis B vaccine for adults that needs only two doses, one month apart, instead of three over six months.
What the price covers
The price is for the vaccine dose. Giving the shot is usually a separate line (code 90471 for the first vaccine of the visit, 90472 for each additional one).