Lab tests CPT 81420 Outpatient

NIPT prenatal DNA test cost in Chicago, IL

In Chicago-Naperville-Elgin, IL-IN, 32 hospitals list a cash price for prenatal cell-free DNA screen for trisomy 21, 18 and 13 (NIPT): from $400.00 to $1,380.00, with a median of $615.77. The lowest listed price is at Uchicago Medicine AdventHealth Bolingbrook and 3 other hospitals — $215.77 less than the median here. Across Illinois, the median is $669.44 at 35 hospitals.

Cash prices at 32 facilities across 27 cities for code 81420, as an outpatient — the setting a self-pay patient normally buys. Collected Sep 23, 2026; the hospital files themselves were last updated between Mar 17, 2025 and Sep 1, 2026.

Lowest$400.00Uchicago Medicine AdventHealth Bolingbrook + 3 more
Median$615.77half pay less
Highest$1,380.00in this market
Difference3.4×highest vs lowest

Where each hospital's price falls

Each dot is one hospital's cash price on a scale from the lowest to the highest in Chicago-Naperville-Elgin, IL-IN.

median
Lowest $400.00Highest $2,527.70

Hospitals, cheapest first

HospitalCash price List priceInsurers payOff listFile date
Uchicago Medicine AdventHealth Bolingbrook lowest Bolingbrook, IL · (630) 312-5000 HC MOLECULAR PATHOLOGY - FETAL CHROMOSOME ANEUPLOIDY $400.00 $1,600.00 — 75% Apr 1, 2026
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Uchicago Medicine AdventHealth Hinsdale lowest Hinsdale, IL · (630) 856-9000 HC MOLECULAR PATHOLOGY - FETAL CHROMOSOME ANEUPLOIDY $400.00 $1,600.00 — 75% Apr 1, 2026
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Uchicago Medicine AdventHealth Glenoaks lowest Glendale Heights, IL · (630) 545-8000 HC MOLECULAR PATHOLOGY - FETAL CHROMOSOME ANEUPLOIDY $400.00 $1,600.00 — 75% Apr 1, 2026
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Uchicago Medicine AdventHealth Glenoaks lowest Glendale Heights, IL · (630) 545-8000 HC MOLECULAR PATHOLOGY - FETAL CHROMOSOME ANEUPLOIDY $400.00 $1,600.00 — 75% Apr 1, 2026
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Uchicago Medicine AdventHealth La Grange lowest La Grange, IL · (708) 352-1200 HC MOLECULAR PATHOLOGY - FETAL CHROMOSOME ANEUPLOIDY $400.00 $1,600.00 — 75% Apr 1, 2026
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Uchicago Medicine AdventHealth La Grange lowest La Grange, IL · (708) 352-1200 HC MOLECULAR PATHOLOGY - FETAL CHROMOSOME ANEUPLOIDY $400.00 $1,600.00 — 75% Apr 1, 2026
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Uchicago Medicine AdventHealth Bolingbrook lowest Bolingbrook, IL · (630) 312-5000 HC MOLECULAR PATHOLOGY - FETAL CHROMOSOME ANEUPLOIDY $400.00 $1,600.00 — 75% Apr 1, 2026
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Uchicago Medicine AdventHealth Hinsdale lowest Hinsdale, IL · (630) 856-9000 HC MOLECULAR PATHOLOGY - FETAL CHROMOSOME ANEUPLOIDY $400.00 $1,600.00 — 75% Apr 1, 2026
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Advocate Sherman Hospital Elgin, IL · (847) 742-9800 FETAL CHROMOSOMAL ANEUPLOIDY GENOMIC SEQ $462.50 $925.00 $283.05–$3,449.46 50% Nov 4, 2025
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Advocate Condell Medical Center Libertyville, IL · (847) 362-2900 FETAL CHROMOSOMAL ANEUPLOIDY GENOMIC SEQ $462.50 $925.00 $364.45–$3,449.46 50% Nov 4, 2025
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Advocate Trinity Hospital Chicago, IL · (773) 967-5002 FETAL CHROMOSOMAL ANEUPLOIDY GENOMIC SEQ $462.50 $925.00 $364.45–$3,449.46 50% Nov 4, 2025
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Advocate South Suburban Hospital Hazel Crest, IL FETAL CHROMOSOMAL ANEUPLOIDY GENOMIC SEQ $462.50 $925.00 $364.45–$3,449.46 50% Nov 4, 2025
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Advocate Childrens Hospital Oak Lawn Oak Lawn, IL FETAL CHROMOSOMAL ANEUPLOIDY GENOMIC SEQ $462.50 $925.00 $364.45–$3,449.46 50% Nov 4, 2025
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Advocate Good Samaritan Hospital Downers Grove, IL · (630) 275-5900 FETAL CHROMOSOMAL ANEUPLOIDY GENOMIC SEQ $462.50 $925.00 $364.45–$3,449.46 50% Nov 4, 2025
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Advocate Illinois Masonic Medical Center Chicago, IL · (773) 975-1600 FETAL CHROMOSOMAL ANEUPLOIDY GENOMIC SEQ $462.50 $925.00 $364.45–$3,449.46 50% Nov 4, 2025
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Advocate Christ Medical Center Oak Lawn, IL · (708) 684-8000 FETAL CHROMOSOMAL ANEUPLOIDY GENOMIC SEQ $462.50 $925.00 $364.45–$3,449.46 50% Nov 4, 2025
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Advocate Good Shepherd Hospital Barrington, IL · (847) 381-9600 FETAL CHROMOSOMAL ANEUPLOIDY GENOMIC SEQ $462.50 $925.00 $364.45–$3,449.46 50% Nov 4, 2025
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Advocate Lutheran General Hospital Park Ridge, IL · (847) 723-2210 FETAL CHROMOSOMAL ANEUPLOIDY GENOMIC SEQ $462.50 $925.00 $364.45–$3,449.46 50% Nov 4, 2025
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Advocate Childrens Hospital Park Ridge Park Ridge, IL FETAL CHROMOSOMAL ANEUPLOIDY GENOMIC SEQ $462.50 $925.00 $364.45–$3,449.46 50% Nov 4, 2025
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Northwestern Medicine McHenry Hospital McHenry, IL · (815) 344-5000 HB Ref Maternit21 Plus Core + Ess + Sca, Fetal Chrmoml Aneuploidy (Lc-Z) $562.10 $803.00 $154.98–$803.00 30% Apr 1, 2026
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Northwestern Medicine McHenry Hospital McHenry, IL · (815) 344-5000 HB Ref Maternit21 Plus, Fetal Chromosome Anuploidy (Lc-Z) $562.10 $803.00 $154.98–$803.00 30% Apr 1, 2026
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Humboldt Park Health North Francisco Chicago, IL · (773) 292-8200 Test for detecting genes associated with fetal disease, aneuploidy genomic sequence analysis panel $669.44 $2,390.85 $2,390.85 72% Aug 24, 2026
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Mercy Medical Center Aurora, IL · (630) 859-2222 NIPT FETAL ANEUPLOIDY $759.00 $2,180.00 $436.00–$2,180.00 65% Sep 1, 2026
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Mercy Medical Center Aurora, IL · (630) 859-2222 FETAL CHRMOML ANEUPLOIDY $759.00 $2,180.00 $436.00–$2,180.00 65% Sep 1, 2026
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Presence Saint Joseph Hospital - Chicago Chicago, IL · (773) 665-3000 HC FETAL CHROMOSOMAL ANEUPLOIDY $770.55 $2,335.00 $759.05–$1,100.62 67% —
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Presence Saint Joseph Hospital - Chicago Chicago, IL · (773) 665-3000 HC FETAL CHROMOSOMAL ANEUPLOIDY $770.55 $2,335.00 $759.05–$1,100.62 67% —
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Palos Community Hospital Palos Heights, IL · (708) 923-4000 HB Ref Qnataltm Advanced, Fetal Chromosomal Aneuploidy (Q-Z) $800.10 $1,143.00 $182.88–$1,143.00 30% Apr 1, 2026
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Louis A Weiss Memorial Hospital Chicago, IL · (773) 878-8700 MaterniT21 PLUS Core+SCA SO $805.42 $2,368.88 $393.94–$1,539.77 66% Mar 17, 2025
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Resilience Healthcare West Suburban Medical Center Oak Park, IL · (708) 383-6200 MaterniT21 PLUS Core+SCA SO $805.42 $2,368.88 $351.54–$1,539.77 66% Mar 17, 2025
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The Methodist Hospitals Merrillville, IN HC Fetal Chromosomal Aneuploidy Genomic Sequence Analysis Panel $835.10 $1,193.00 $458.11–$2,003.90 30% —
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The Methodist Hospitals Gary, IN · (219) 886-4000 HC Maternit 21 Plus Core + Sca (Mt21s) $835.10 $1,193.00 $458.11–$2,003.90 30% —
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The Methodist Hospitals Gary, IN · (219) 886-4000 HC Maternit 21 Plus Core + Sca, No Gender (M21sng) $835.10 $1,193.00 $458.11–$2,003.90 30% —
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The Methodist Hospitals Merrillville, IN HC Maternit 21 Plus Core + Sca, No Gender (M21sng) $835.10 $1,193.00 $458.11–$2,003.90 30% —
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The Methodist Hospitals Merrillville, IN HC Maternit 21 Plus Core + Sca (Mt21s) $835.10 $1,193.00 $458.11–$2,003.90 30% —
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The Methodist Hospitals Gary, IN · (219) 886-4000 HC Fetal Chromosomal Aneuploidy Genomic Sequence Analysis Panel $835.10 $1,193.00 $458.11–$2,003.90 30% —
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Northwestern Medicine Delnor Hospital Geneva, IL · (630) 208-3000 HB Ref Maternit Genome, Fetal Chromosomal Aneuploidy (Lc-Z) $879.90 $1,257.00 $187.29–$1,257.00 30% Apr 1, 2026
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Northwestern Medicine Kishwaukee Hospital DeKalb, IL · (815) 756-1521 HB Ref Maternit Genome, Fetal Chromosomal Aneuploidy (Lc-Z) $879.90 $1,257.00 $230.03–$1,257.00 30% Apr 1, 2026
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Northwestern Medicine Kishwaukee Hospital DeKalb, IL · (815) 756-1521 HB Ref Maternit21 Plus Core (Lc-Z) $879.90 $1,257.00 $230.03–$1,257.00 30% Apr 1, 2026
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Palos Community Hospital Palos Heights, IL · (708) 923-4000 HB Ref Maternit Genome, Fetal Chromosomal Aneuploidy (Lc-Z) $879.90 $1,257.00 $201.12–$1,257.00 30% Apr 1, 2026
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Palos Community Hospital Palos Heights, IL · (708) 923-4000 HB Ref Maternit21 Plus Core (Lc-Z) $879.90 $1,257.00 $201.12–$1,257.00 30% Apr 1, 2026
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Northwestern Medicine Marianjoy Rehabilitation Hospital Wheaton, IL HB Ref Maternit Genome, Fetal Chromosomal Aneuploidy (Lc-Z) $879.90 $1,257.00 $527.94–$1,257.00 30% Apr 1, 2026
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Northwestern Medicine Marianjoy Rehabilitation Hospital Wheaton, IL HB Ref Maternit21 Plus Core (Lc-Z) $879.90 $1,257.00 $527.94–$1,257.00 30% Apr 1, 2026
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Northwestern Medicine Delnor Hospital Geneva, IL · (630) 208-3000 HB Ref Maternit21 Plus, Fetal Chromosome Anuploidy (Lc-Z) $879.90 $1,257.00 $187.29–$1,257.00 30% Apr 1, 2026
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Northwestern Medicine Delnor Hospital Geneva, IL · (630) 208-3000 HB Ref Qnataltm Advanced, Fetal Chromosomal Aneuploidy (Q-Z) $879.90 $1,257.00 $187.29–$1,257.00 30% Apr 1, 2026
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Northwestern Medicine Delnor Hospital Geneva, IL · (630) 208-3000 HB Ref Maternit21 Plus Core + Sca (Lc-Z) $879.90 $1,257.00 $187.29–$1,257.00 30% Apr 1, 2026
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Northwestern Medicine Delnor Hospital Geneva, IL · (630) 208-3000 HB Ref Maternit21 Plus Core (Lc-Z) $879.90 $1,257.00 $187.29–$1,257.00 30% Apr 1, 2026
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Northwestern Medicine Delnor Hospital Geneva, IL · (630) 208-3000 HB Ref Maternit21 Plus Core + Ess + Sca, Fetal Chrmoml Aneuploidy (Lc-Z) $879.90 $1,257.00 $187.29–$1,257.00 30% Apr 1, 2026
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Northwestern Medicine Valley West Hospital Sandwich, IL · (815) 786-8484 HB Ref Maternit Genome, Fetal Chromosomal Aneuploidy (Lc-Z) $879.90 $1,257.00 $238.83–$1,257.00 30% Apr 1, 2026
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Northwestern Medicine Valley West Hospital Sandwich, IL · (815) 786-8484 HB Ref Maternit21 Plus Core (Lc-Z) $879.90 $1,257.00 $238.83–$1,257.00 30% Apr 1, 2026
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Northwestern Lake Forest Hospital Lake Forest, IL · (847) 234-5600 HB Ref Maternit Genome, Fetal Chromosomal Aneuploidy (Lc-Z) $879.90 $1,257.00 $208.66–$1,257.00 30% Apr 1, 2026
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Northwestern Lake Forest Hospital Lake Forest, IL · (847) 234-5600 HB Ref Maternit21 Plus Core (Lc-Z) $879.90 $1,257.00 $208.66–$1,257.00 30% Apr 1, 2026
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Northwestern Medicine McHenry Hospital McHenry, IL · (815) 344-5000 HB Ref Maternit Genome, Fetal Chromosomal Aneuploidy (Lc-Z) $879.90 $1,257.00 $242.60–$1,257.00 30% Apr 1, 2026
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Northwestern Medicine McHenry Hospital McHenry, IL · (815) 344-5000 HB Ref Maternit21 Plus Core (Lc-Z) $879.90 $1,257.00 $242.60–$1,257.00 30% Apr 1, 2026
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Northwestern Medicine Central DuPage Hospital Winfield, IL · (630) 682-1600 HB Ref Maternit21 Plus, Fetal Chromosome Anuploidy (Lc-Z) $879.90 $1,257.00 $86.73–$1,257.00 30% Apr 1, 2026
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Northwestern Medicine Central DuPage Hospital Winfield, IL · (630) 682-1600 HB Ref Qnataltm Advanced, Fetal Chromosomal Aneuploidy (Q-Z) $879.90 $1,257.00 $86.73–$1,257.00 30% Apr 1, 2026
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Northwestern Medicine Central DuPage Hospital Winfield, IL · (630) 682-1600 HB Ref Maternit Genome, Fetal Chromosomal Aneuploidy (Lc-Z) $879.90 $1,257.00 $86.73–$1,257.00 30% Apr 1, 2026
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Northwestern Medicine Central DuPage Hospital Winfield, IL · (630) 682-1600 HB Ref Maternit21 Plus Core + Sca (Lc-Z) $879.90 $1,257.00 $86.73–$1,257.00 30% Apr 1, 2026
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Northwestern Medicine Central DuPage Hospital Winfield, IL · (630) 682-1600 HB Ref Maternit21 Plus Core (Lc-Z) $879.90 $1,257.00 $86.73–$1,257.00 30% Apr 1, 2026
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Northwestern Medicine Central DuPage Hospital Winfield, IL · (630) 682-1600 HB Ref Maternit21 Plus Core + Ess + Sca, Fetal Chrmoml Aneuploidy (Lc-Z) $879.90 $1,257.00 $86.73–$1,257.00 30% Apr 1, 2026
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Palos Community Hospital Palos Heights, IL · (708) 923-4000 HB Ref Prequel Prenatal Screen (Myriad) $926.80 $1,324.00 $211.84–$1,324.00 30% Apr 1, 2026
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Northwestern Medicine Delnor Hospital Geneva, IL · (630) 208-3000 HB Ref Prequel Prenatal Screen (Myriad) $926.80 $1,324.00 $197.28–$1,324.00 30% Apr 1, 2026
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Northwestern Medicine Valley West Hospital Sandwich, IL · (815) 786-8484 HB Ref Prequel Prenatal Screen (Myriad) $926.80 $1,324.00 $251.56–$1,324.00 30% Apr 1, 2026
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Northwestern Medicine Marianjoy Rehabilitation Hospital Wheaton, IL HB Ref Prequel Prenatal Screen (Myriad) $926.80 $1,324.00 $556.08–$1,324.00 30% Apr 1, 2026
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Northwestern Medicine McHenry Hospital McHenry, IL · (815) 344-5000 HB Ref Prequel Prenatal Screen (Myriad) $926.80 $1,324.00 $255.53–$1,324.00 30% Apr 1, 2026
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Northwestern Medicine Kishwaukee Hospital DeKalb, IL · (815) 756-1521 HB Ref Prequel Prenatal Screen (Myriad) $926.80 $1,324.00 $242.29–$1,324.00 30% Apr 1, 2026
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Northwestern Lake Forest Hospital Lake Forest, IL · (847) 234-5600 HB Ref Prequel Prenatal Screen (Myriad) $926.80 $1,324.00 $219.78–$1,324.00 30% Apr 1, 2026
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Northwestern Medicine Central DuPage Hospital Winfield, IL · (630) 682-1600 HB Ref Prequel Prenatal Screen (Myriad) $926.80 $1,324.00 $91.36–$1,324.00 30% Apr 1, 2026
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Northwestern Medicine McHenry Hospital McHenry, IL · (815) 344-5000 HB Ref Maternit21 Plus Core + Sca (Lc-Z) $1,124.20 $1,606.00 $309.96–$1,606.00 30% Apr 1, 2026
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Ingalls Memorial Hospital Harvey, IL · (708) 333-2300 Hc Fetal Chromosomal Aneuploidy Genomic Seq Analys $1,258.00 $1,258.00 — — Apr 1, 2026
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Ingalls Memorial Hospital Harvey, IL · (708) 333-2300 Noncdm Charge Record $1,258.00 $1,258.00 — — Apr 1, 2026
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Northwest Community Hospital Arlington Heights, IL · (847) 618-1000 Hb Fetal Chrmoml Aneuploidy $1,380.00 $1,380.00 — — Apr 1, 2026
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The Methodist Hospitals Merrillville, IN HC Maternit 21 Plus Core, No Gender (Mt21ng) $1,475.60 $2,108.00 $759.05–$2,003.90 30% —
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The Methodist Hospitals Gary, IN · (219) 886-4000 HC Maternit 21 Plus Core, No Gender (Mt21ng) $1,475.60 $2,108.00 $759.05–$2,003.90 30% —
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Northwestern Medicine McHenry Hospital McHenry, IL · (815) 344-5000 HB Ref Qnataltm Advanced, Fetal Chromosomal Aneuploidy (Q-Z) $1,528.10 $2,183.00 $421.32–$2,183.00 30% Apr 1, 2026
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The Methodist Hospitals Gary, IN · (219) 886-4000 Fetal Chrmoml Aneuploidy $1,659.00 $2,370.00 $759.05–$2,142.26 30% —
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The Methodist Hospitals Merrillville, IN Fetal Chrmoml Aneuploidy $1,659.00 $2,370.00 $759.05–$2,142.26 30% —
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Northwestern Medicine Central DuPage Hospital Winfield, IL · (630) 682-1600 HB Ref Panorama Extended, Fetal Chromosomal Aneuploidy (Nat) $1,968.40 $2,812.00 $194.03–$2,812.00 30% Apr 1, 2026
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Palos Community Hospital Palos Heights, IL · (708) 923-4000 HB Ref Panorama Extended, Fetal Chromosomal Aneuploidy (Nat) $1,968.40 $2,812.00 $449.92–$2,812.00 30% Apr 1, 2026
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Northwestern Medicine Kishwaukee Hospital DeKalb, IL · (815) 756-1521 HB Ref Panorama Extended, Fetal Chromosomal Aneuploidy (Nat) $1,968.40 $2,812.00 $514.60–$2,812.00 30% Apr 1, 2026
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Northwestern Lake Forest Hospital Lake Forest, IL · (847) 234-5600 HB Ref Panorama Extended, Fetal Chromosomal Aneuploidy (Nat) $1,968.40 $2,812.00 $466.79–$2,812.00 30% Apr 1, 2026
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Northwestern Medicine Marianjoy Rehabilitation Hospital Wheaton, IL HB Ref Panorama Extended, Fetal Chromosomal Aneuploidy (Nat) $1,968.40 $2,812.00 $1,181.04–$2,812.00 30% Apr 1, 2026
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Northwestern Medicine McHenry Hospital McHenry, IL · (815) 344-5000 HB Ref Panorama Extended, Fetal Chromosomal Aneuploidy (Nat) $1,968.40 $2,812.00 $542.72–$2,812.00 30% Apr 1, 2026
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Northwestern Medicine Valley West Hospital Sandwich, IL · (815) 786-8484 HB Ref Panorama Extended, Fetal Chromosomal Aneuploidy (Nat) $1,968.40 $2,812.00 $534.28–$2,812.00 30% Apr 1, 2026
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Northwestern Medicine Delnor Hospital Geneva, IL · (630) 208-3000 HB Ref Panorama Extended, Fetal Chromosomal Aneuploidy (Nat) $1,968.40 $2,812.00 $418.99–$2,812.00 30% Apr 1, 2026
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Northwestern Medicine McHenry Hospital McHenry, IL · (815) 344-5000 HB Ref Fetal Chromosomal Aneuploidy $2,207.80 $3,154.00 $608.72–$3,154.00 30% Apr 1, 2026
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Northwestern Medicine Central DuPage Hospital Winfield, IL · (630) 682-1600 HB Ref Informaseq Prenatal Test (Lc) $2,207.80 $3,154.00 $217.63–$3,154.00 30% Apr 1, 2026
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Northwestern Medicine Valley West Hospital Sandwich, IL · (815) 786-8484 HB Ref Fetal Chromosomal Aneuploidy $2,207.80 $3,154.00 $599.26–$3,154.00 30% Apr 1, 2026
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Northwestern Medicine Marianjoy Rehabilitation Hospital Wheaton, IL HB Ref Fetal Chromosomal Aneuploidy $2,207.80 $3,154.00 $1,324.68–$3,154.00 30% Apr 1, 2026
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Northwestern Lake Forest Hospital Lake Forest, IL · (847) 234-5600 HB Ref Fetal Chromosomal Aneuploidy $2,207.80 $3,154.00 $523.56–$3,154.00 30% Apr 1, 2026
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Northwestern Medicine Kishwaukee Hospital DeKalb, IL · (815) 756-1521 HB Ref Fetal Chromosomal Aneuploidy $2,207.80 $3,154.00 $577.18–$3,154.00 30% Apr 1, 2026
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Northwestern Medicine Delnor Hospital Geneva, IL · (630) 208-3000 HB Ref Informaseq Prenatal Test (Lc) $2,207.80 $3,154.00 $469.95–$3,154.00 30% Apr 1, 2026
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Palos Community Hospital Palos Heights, IL · (708) 923-4000 HB Ref Fetal Chromosomal Aneuploidy $2,207.80 $3,154.00 $504.64–$3,154.00 30% Apr 1, 2026
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Northwestern Medicine Delnor Hospital Geneva, IL · (630) 208-3000 HB Ref Fetal Chromosomal Aneuploidy $2,207.80 $3,154.00 $469.95–$3,154.00 30% Apr 1, 2026
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Northwestern Medicine Central DuPage Hospital Winfield, IL · (630) 682-1600 HB Ref Fetal Chromosomal Aneuploidy $2,207.80 $3,154.00 $217.63–$3,154.00 30% Apr 1, 2026
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Northwestern Lake Forest Hospital Lake Forest, IL · (847) 234-5600 HB Ref Informaseq Prenatal Test (Lc) $2,527.70 $3,611.00 $599.43–$3,611.00 30% Apr 1, 2026
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Outpatient: lowest $400.00, median $615.77, highest $1,380.00 — a 3.4× difference within the same market.

As an inpatient, the same code is billed by 20 facilities here, median $462.50. Inpatient and outpatient prices are not comparable and are kept on separate pages: the inpatient charge covers admission, not the same purchase.

Cash or insurance?

At 26 of 26 hospitals that publish insurer rates for this code here, the cash price is below the highest rate a health plan has negotiated, and at 1 it is below every plan's rate. If you have insurance but have not met your deductible, you usually pay your plan's negotiated rate, which falls somewhere in the "Insurers pay" column. Paying cash can cost less, but a cash payment usually does not count toward your deductible. Ask the hospital for both numbers before you book.

What it is

NIPT analyzes fragments of fetal DNA that circulate in the mother's blood to screen for Down syndrome (trisomy 21) and trisomies 18 and 13. It can be done from about 10 weeks of pregnancy. It is a screening test, so a positive result needs a diagnostic test to confirm.

What the price covers

The price usually covers the DNA analysis of one blood sample. The blood draw, genetic counseling and any added screens, such as sex chromosomes or microdeletions, may be billed separately.