Hepatitis B vaccine (Heplisav-B) cost in Boston, MA
In Boston-Cambridge-Newton, MA-NH, 10 hospitals list a cash price for hepatitis B vaccine, adult, 2-dose schedule (Heplisav-B): from $108.68 to $926.75, with a median of $315.59. The lowest listed price is at Boston Medical Center Brighton — $206.91 less than the median here. Across Massachusetts, the median is $315.59 at 14 hospitals.
Cash prices at 10 facilities across 8 cities for code 90739, as an outpatient — the setting a self-pay patient normally buys. Collected Sep 29, 2026; the hospital files themselves were last updated between Jan 28, 2026 and Sep 1, 2026.
Where each hospital's price falls
Each dot is one hospital's cash price on a scale from the lowest to the highest in Boston-Cambridge-Newton, MA-NH.
Hospitals, cheapest first
| Hospital | Cash price | List price | Insurers pay | Off list | File date |
|---|---|---|---|---|---|
| Boston Medical Center Brighton lowest Boston, MA · (617) 789-3000 HC Hepatitis B Vaccine Adult 2 Dose Im | $108.68 | $241.50 | $159.68–$475.07 | 55% | — source file |
| Signature Healthcare Brockton Hospital Brockton, MA · (508) 941-7000 HEPLISAV-B 20mcg (HEP B VACC) | $130.83 | $186.90 | $69.15–$217.50 | 30% | Jan 28, 2026 source file |
| Boston Medical Center Boston, MA · (617) 638-8000 HEPATITIS B VACCINE 20 MCG/0.5 ML-ADJUVANT CPG 1018 (PF) IM SYRINGE | $152.87 | $339.70 | $113.27–$512.54 | 55% | — source file |
| Boston Medical Center Boston, MA · (617) 638-8000 HC Hepatitis B Vaccine Adult 2 Dose Im | $184.05 | $409.00 | $113.27–$512.54 | 55% | — source file |
| Southcoast Hospitals Group - Tobey Hospital Campus Wareham, MA · (508) 679-3131 HEPATITIS B VAC RECOMB ADJ 20 MCG/0.5ML IM SOSY | $280.71 | $561.42 | $0.50–$427.24 | 50% | — source file |
| Cambridge Health Alliance Cambridge, MA · (617) 665-1000 HC Hepb Vaccine Adult 2 Dose Schedule for Im Use | $300.00 | $300.00 | $142.44–$377.25 | — | — source file |
| Tufts Medical Center Boston, MA · (617) 636-5000 HEPATITIS B VACCINE 20 MCG/0.5 ML-ADJUVANT CPG 101 | $331.17 | $473.10 | $124.24–$473.10 | 30% | — source file |
| Melrosewakefield Healthcare Melrose, MA · (781) 979-3000 HEPATITIS B VACCINE 20 MCG/0.5 ML-ADJUVANT CPG 101 | $331.17 | $473.10 | $146.99–$530.75 | 30% | — source file |
| Lowell General Hospital Lowell, MA · (978) 937-6000 HEPATITIS B VACCINE 20 MCG/0.5 ML-ADJUVANT CPG 101 | $331.17 | $473.10 | $139.53–$473.10 | 30% | — source file |
| Lowell General Hospital Lowell, MA · (978) 937-6000 HC Pbb Imm Hepb Vaccine Adult 2 Dose Schedule for | $634.16 | $905.94 | $139.53–$905.94 | 30% | — source file |
| Melrosewakefield Healthcare Melrose, MA · (781) 979-3000 HC Pbb Imm Hepb Vaccine Adult 2 Dose Schedule for | $634.16 | $905.94 | $146.99–$979.59 | 30% | — source file |
| Tufts Medical Center Boston, MA · (617) 636-5000 HC Pbb Imm Hepb Vaccine Adult 2 Dose Schedule for | $634.16 | $905.94 | $0.01–$905.94 | 30% | — source file |
| Plaistow Fser Plaistow, NH · (603) 421-2100 HEPLISAV-B ADULT IM | $926.75 | $926.75 | $28.64–$880.41 | — | Sep 1, 2026 source file |
| Parkland Medical Center Derry, NH · (603) 421-2100 Hepatitis B vaccine (HepB), CpG-adjuvanted, adult dosage, 2 dose or 4 dose schedule, for intramuscular use | $926.75 | $926.75 | $172.23–$481.98 | — | Sep 1, 2026 source file |
| Plaistow Fser Plaistow, NH · (603) 421-2100 Hepatitis B vaccine (HepB), CpG-adjuvanted, adult dosage, 2 dose or 4 dose schedule, for intramuscular use | $926.75 | $926.75 | $172.23–$481.98 | — | Sep 1, 2026 source file |
| Parkland Medical Center Derry, NH · (603) 421-2100 HEPLISAV-B ADULT IM | $926.75 | $926.75 | $28.64–$880.41 | — | Sep 1, 2026 source file |
Outpatient: lowest $108.68, median $315.59, highest $926.75 — a 8.5× difference within the same market.
As an inpatient, the same code is billed by 7 facilities here, median $300.00. Inpatient and outpatient prices are not comparable and are kept on separate pages: the inpatient charge covers admission, not the same purchase.
Cash or insurance?
At 8 of 10 hospitals that publish insurer rates for this code here, the cash price is below the highest rate a health plan has negotiated, and at 1 it is below every plan's rate. If you have insurance but have not met your deductible, you usually pay your plan's negotiated rate, which falls somewhere in the "Insurers pay" column. Paying cash can cost less, but a cash payment usually does not count toward your deductible. Ask the hospital for both numbers before you book.
What it is
Heplisav-B is a hepatitis B vaccine for adults that needs only two doses, one month apart, instead of three over six months.
What the price covers
The price is for the vaccine dose. Giving the shot is usually a separate line (code 90471 for the first vaccine of the visit, 90472 for each additional one).