Hepatitis B vaccine (Heplisav-B) cost in San Antonio, TX
In San Antonio-New Braunfels, TX, 4 hospitals list a cash price for hepatitis B vaccine, adult, 2-dose schedule (Heplisav-B): from $78.00 to $867.87, with a median of $521.35. The lowest listed price is at University Health System — $443.35 less than the median here. Across Texas, the median is $402.20 at 61 hospitals.
Cash prices at 4 facilities across 3 cities for code 90739, as an outpatient — the setting a self-pay patient normally buys. Collected Sep 27, 2026; the hospital files themselves were last updated between Oct 14, 2025 and Sep 1, 2026.
Where each hospital's price falls
Each dot is one hospital's cash price on a scale from the lowest to the highest in San Antonio-New Braunfels, TX.
Hospitals, cheapest first
| Hospital | Cash price | List price | Insurers pay | Off list | File date |
|---|---|---|---|---|---|
| University Health System lowest San Antonio, TX · (210) 358-2000 HC PBB HEPB VACCINE ADULT 2 DOSE SCHEDULE FOR IM U | $78.00 | $312.00 | $115.44–$780.00 | 75% | Oct 14, 2025 source file |
| Medina Regional Hospital Hondo, TX · (830) 426-7700 HEPB VACC 2/4 DOSE ADULT IM | $174.83 | $194.25 | $46.62–$194.25 | 10% | Jul 29, 2026 source file |
| University Health System San Antonio, TX · (210) 358-2000 Hepatitis B vaccine (HepB), adult dosage, 2 dose schedule IM | $225.03 | $900.12 | $177.56–$2,250.30 | 75% | Oct 14, 2025 source file |
| Methodist Hospital Helotes, TX · (210) 575-4000 Hepatitis B vaccine (HepB), CpG-adjuvanted, adult dosage, 2 dose or 4 dose schedule, for intramuscular use | $867.87 | $867.87 | $292.97 | — | Sep 1, 2026 source file |
| Methodist Specialty and Transplant San Antonio, TX · (210) 575-4000 HEPLISAV-B ADULT IM | $867.87 | $867.87 | $43.39–$867.87 | — | Sep 1, 2026 source file |
| Methodist Hospital Helotes, TX · (210) 575-4000 HEPLISAV-B ADULT IM | $867.87 | $867.87 | $43.39–$867.87 | — | Sep 1, 2026 source file |
| Methodist Specialty and Transplant San Antonio, TX · (210) 575-4000 Hepatitis B vaccine (HepB), CpG-adjuvanted, adult dosage, 2 dose or 4 dose schedule, for intramuscular use | $867.87 | $867.87 | $292.97 | — | Sep 1, 2026 source file |
Outpatient: lowest $78.00, median $521.35, highest $867.87 — a 11.1× difference within the same market.
As an inpatient, the same code is billed by 2 facilities here, median $126.42. Inpatient and outpatient prices are not comparable and are kept on separate pages: the inpatient charge covers admission, not the same purchase.
Cash or insurance?
At 2 of 4 hospitals that publish insurer rates for this code here, the cash price is below the highest rate a health plan has negotiated, and at 1 it is below every plan's rate. If you have insurance but have not met your deductible, you usually pay your plan's negotiated rate, which falls somewhere in the "Insurers pay" column. Paying cash can cost less, but a cash payment usually does not count toward your deductible. Ask the hospital for both numbers before you book.
What it is
Heplisav-B is a hepatitis B vaccine for adults that needs only two doses, one month apart, instead of three over six months.
What the price covers
The price is for the vaccine dose. Giving the shot is usually a separate line (code 90471 for the first vaccine of the visit, 90472 for each additional one).