NIPT prenatal DNA test cost in Orlando, FL
In Orlando-Kissimmee-Sanford, FL, 7 hospitals list a cash price for prenatal cell-free DNA screen for trisomy 21, 18 and 13 (NIPT): from $319.20 to $783.00, with a median of $319.20. The lowest listed price is at Orlando Health and 3 other hospitals. Across Florida, the median is $412.50 at 45 hospitals.
Cash prices at 7 facilities across 6 cities for code 81420, as an outpatient — the setting a self-pay patient normally buys. Collected Sep 23, 2026; the hospital files themselves were last updated between Mar 31, 2026 and Apr 1, 2026.
Where each hospital's price falls
Each dot is one hospital's cash price on a scale from the lowest to the highest in Orlando-Kissimmee-Sanford, FL.
Hospitals, cheapest first
| Hospital | Cash price | List price | Insurers pay | Off list | File date |
|---|---|---|---|---|---|
| Orlando Health lowest Orlando, FL · (321) 841-5111 Hb Fetal Chrom Aneuploidy-Ref | $319.20 | $798.00 | — | 60% | Apr 1, 2026 source file |
| Orlando Health St Cloud Hospital lowest Saint Cloud, FL · (407) 892-2135 Hb Fetal Chrom Aneuploidy-Ref | $319.20 | $798.00 | — | 60% | Apr 1, 2026 source file |
| Orlando Health Central lowest Ocoee, FL · (407) 296-1000 Hb Fetal Chrom Aneuploidy-Ref | $319.20 | $798.00 | — | 60% | Apr 1, 2026 source file |
| South Lake Hospital lowest Clermont, FL · (352) 394-4071 Hb Fetal Chrom Aneuploidy-Ref | $319.20 | $798.00 | — | 60% | Apr 1, 2026 source file |
| UF Health The Villages, FL · (352) 751-8000 UF HB FETAL CHRMOML ANEUPLOIDY | $412.50 | $750.00 | $342.31–$834.96 | 45% | Mar 31, 2026 source file |
| UF Health Leesburg, FL · (352) 323-5762 UF HB FETAL CHRMOML ANEUPLOIDY | $412.50 | $750.00 | $342.31–$834.96 | 45% | Mar 31, 2026 source file |
| UF Health Leesburg, FL · (352) 323-5762 UF HB FETAL ANEUPLOIDY CHROMOSOME DETECTION | $531.85 | $967.00 | $435.15–$670.13 | 45% | Mar 31, 2026 source file |
| UF Health The Villages, FL · (352) 751-8000 UF HB FETAL ANEUPLOIDY CHROMOSOME DETECTION | $531.85 | $967.00 | $342.31–$834.96 | 45% | Mar 31, 2026 source file |
| AdventHealth Orlando Orlando, FL · (407) 303-1976 HC MOLECULAR PATHOLOGY - FETAL CHROMOSOME ANEUPLOIDY | $783.00 | $783.00 | — | — | Apr 1, 2026 source file |
| AdventHealth Orlando Orlando, FL · (407) 303-1976 HC FETAL ANEUPLOIDY -NIPT FETAL ANEUPLOIDY SCREENING W MICRODELETIONS -ARUP | $1,154.00 | $1,154.00 | — | — | Apr 1, 2026 source file |
Outpatient: lowest $319.20, median $319.20, highest $783.00 — a 2.5× difference within the same market.
As an inpatient, the same code is billed by 5 facilities here, median $319.20. Inpatient and outpatient prices are not comparable and are kept on separate pages: the inpatient charge covers admission, not the same purchase.
Cash or insurance?
At 2 of 2 hospitals that publish insurer rates for this code here, the cash price is below the highest rate a health plan has negotiated, and at none is it below every plan's rate. If you have insurance but have not met your deductible, you usually pay your plan's negotiated rate, which falls somewhere in the "Insurers pay" column. Paying cash can cost less, but a cash payment usually does not count toward your deductible. Ask the hospital for both numbers before you book.
What it is
NIPT analyzes fragments of fetal DNA that circulate in the mother's blood to screen for Down syndrome (trisomy 21) and trisomies 18 and 13. It can be done from about 10 weeks of pregnancy. It is a screening test, so a positive result needs a diagnostic test to confirm.
What the price covers
The price usually covers the DNA analysis of one blood sample. The blood draw, genetic counseling and any added screens, such as sex chromosomes or microdeletions, may be billed separately.